Article
The emerging role of LRRK2 in tauopathies.
Clinical science (London, England : 1979) - 15 Jul 2022
Herbst Susanne, Lewis Patrick A, Morris Huw R
Abstract excerpt
Parkinson's disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson's syndrome including tau pathology resembling progressive supranuclear palsy (PSP)....
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