The biology and pathobiology of LRRK2: implications for Parkinson's disease.

doi:10.1016/j.parkreldis.2008.04.010

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Article

The biology and pathobiology of LRRK2: implications for Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2008

Moore Darren J

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are an important cause of late-onset, familial and sporadic Parkinson's disease. LRRK2 is a large unique protein containing both GTPase and kinase enzymatic domains together with multiple protein-protein interaction domains. LRRK2 initial...

Topics

Animals
Biology
GTP Phosphohydrolases
Genetic Predisposition to Disease
Humans
Inclusion Bodies
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases

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