Article
Mechanisms of LRRK2-mediated neurodegeneration.
Current neurology and neuroscience reports - 1 Jun 2012
Tsika Elpida, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common cause of familial Parkinson's disease (PD), whereas common variation at the LRRK2 locus is associated with an increased risk of idiopathic PD. Considerable progress has been made toward understanding the biological functions of LRRK2 and the molecular mechanisms underlying the pathogenic effects of disease-associated mutations....
Topics
- Autophagy
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mitochondria
- Models, Molecular
- Mutation
- Neurodegenerative Diseases
- Protein Serine-Threonine Kinases