Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function

7 Feb 2017

Abstract excerpt

Abstract BRAF drives tumorigenesis by coordinating the activation of the RAS/RAF/MEK/ERK oncogenic signaling cascade. However, upstream pathways governing BRAF kinase activity and protein stability remain undefined. Here, we report that in primary cells with active APCFZR1, APCFZR1 earmarks BRAF for ubiquitination-mediated proteolysis, whereas in cancer cells with APC-free FZR1, FZR1 suppresses BRAF through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Melanoma and MAPK Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28174173
DOI: 10.1158/2159-8290.cd-16-0647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic FunctionPMID 28174173Read ↗

Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer.Semantic proximity Read ↗

Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stageSemantic proximity Read ↗

LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.Semantic proximity Read ↗

Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).Semantic proximity Read ↗

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family membersSemantic proximity Read ↗

Functional and prognostic significance of the genomic amplification of frizzled 6 ( FZD6 ) in breast cancerSemantic proximity Read ↗

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.Semantic proximity Read ↗

Distinct D-box Motifs in SPD-2 Mediate APC/C <sup>FZR-1</sup> -Dependent Degradation and Centrosomal Localization in <i>Caenorhabditis elegans</i> EmbryosSemantic proximity Read ↗

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolismSemantic proximity Read ↗

Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.Semantic proximity Read ↗

Residue 6.43 defines receptor function in class F GPCRs.Semantic proximity Read ↗

Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.