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Article

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.

Life science alliance - 1 Sept 2024

Bugter Jeroen M, van Kerkhof Peter, Jordens Ingrid, Janssen Eline, Tran Ngoc Minh Thi, Iglesias van Montfort Daniel, Jamieson Cara, Maurice Madelon M

Abstract excerpt

The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for WNT. Loss-of-function mutations in RNF43 and ZNRF3 mediate FZD stabilisation and a WNT-hypersensitive growth state in various cancer types. Strikingly, RNF43 and ZNRF3 mutations are differentially distributed across cancer types, raising...

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Source

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Identifiers

PMID: 38969364
DOI: 10.26508/lsa.202402575
PMCID: PMC11231576

Genes

RNF43
ZNRF3
FZD5
FZD1
FZD6
FZD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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