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Article

Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.

Cellular signalling - 1 Jun 2016

Hernandez Maria Aguilar, Patel Bipin, Hey Fiona, Giblett Susan, Davis Hayley, Pritchard Catrin

Abstract excerpt

The (V600E)BRAF oncogenic mutation is detected in a wide range of human cancers and induces hyperactivation of the downstream MEK-ERK signalling cascade. Although output of the BRAF-MEK-ERK pathway is regulated by feed-forward RAF activity, feedback control also plays an important role. One such feedback pathway has been identified in Caenorhabditis elegans and involves ERK-mediated phosphorylation of BRAF within...

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Source

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Identifiers

PMID: 26898828
DOI: 10.1016/j.cellsig.2016.02.009
PMCID: PMC6399479

Genes

BRAF
CPD
CUL1
SKP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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