Article

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> APC, the core scaffold of the Wnt destruction complex, targets the transcriptional co-activator β-catenin for proteolysis. There is no convincing evidence that APC directs degradation of other substrates. Using a reconstituted cytosolic extract-based system and complementary in vivo and cellular assays, we show that SREBP2, the master regulator of cholesterol biosynthesis, is a direct APC–AXIN1...

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Literature Corpus work: 042af848-992c-57b5-a316-4c847b86a283
DOI: 10.1101/2025.10.12.681896

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