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Article

Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).

The Journal of biological chemistry - 6 Jul 2012

Hong Seung-Woo, Jin Dong-Hoon, Shin Jae-Sik, Moon Jai-Hee, Na Young-Soon, Jung Kyung-Ah, Kim Seung-Mi, Kim Jin Cheon, Kim Kyu-Pyo, Hong Yong Sang, Lee Jae-Lyun, Choi Eun Kyung, Lee Jung Shin, Kim Tae Won

Abstract excerpt

Members of the RAF family (ARAF, BRAF, and CRAF/RAF-1) are involved in a variety of cellular activities, including growth, survival, differentiation, and transformation. An oncogene encodes BRAF, the function of which is linked to MEK activation. BRAF is the most effective RAF kinase in terms of induction of MEK/ERK activity. However, the mechanisms involved in BRAF regulation remain unclear. In the present work,...

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Identifiers

PMID: 22628551
DOI: 10.1074/jbc.M111.319822
PMCID: PMC3390676

Genes

BRAF
ARAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).PMID 22628551Read ↗

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