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Article

Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage

24 Jul 2017

Abstract excerpt

Frizzled receptors are the mediators of the wnt canonical and non-canonical pathways, which play fundamental roles in cell differentiation and organism development. A large body of work indicates that dysregulation of wnt signalling is a feature of oncogenic transformation, but most of the studies published so far focus on the assessment of the consequences of aberrations of the canonical pathway in human cancer....

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PMID: 28737757
DOI: 10.1038/oncsis.2017.69

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