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Article

Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer.

The Journal of biological chemistry - 1 Jan 2000

Zhong Zhendong A, Michalski Megan N, Stevens Payton D, Sall Emily A, Williams Bart O

Abstract excerpt

Hyperactivation of Wnt/β-catenin (canonical) signaling in colorectal cancers (CRCs) was identified in the 1990s. Most CRC patients have mutations in genes that encode components of the Wnt pathway. Inactivating mutations in the adenomatous polyposis coli (APC) gene, which encodes a protein necessary for β-catenin degradation, are by far the most prevalent. Other Wnt signaling components are mutated in a smaller...

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Identifiers

PMID: 34000297
DOI: 10.1016/j.jbc.2021.100782
PMCID: PMC8214085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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