Article

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family members

2023-11-23

Abstract excerpt

The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for WNT. Loss-of-function mutations in RNF43 and ZNRF3 mediate FZD stabilisation and a WNT-hypersensitive growth state in various cancer types. Strikingly, RNF43 and ZNRF3 mutations are differentially distributed across cancer types, raising que...

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Literature Corpus work: 8f54e11e-c34d-5675-a0ee-38943b2ce91b
DOI: 10.1101/2023.11.23.568206

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