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Article

Residue 6.43 defines receptor function in class F GPCRs.

Nature communications - 24 Jun 2021

Turku Ainoleena, Schihada Hannes, Kozielewicz Pawel, Bowin Carl-Fredrik, Schulte Gunnar

Abstract excerpt

The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO), remains one of the most enigmatic GPCR families. While SMO relies on cholesterol binding to the 7TM core of the receptor to activate downstream signaling, underlying details of receptor activation remain obscure for FZDs. Here, we aimed to investigate the activation mechanisms of class F...

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Identifiers

PMID: 34168128
DOI: 10.1038/s41467-021-24004-z
PMCID: PMC8225760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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