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Article

LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.

Cancer discovery - 1 Mar 2023

Ko Aram, Hasanain Mohammad, Oh Young Taek, D'Angelo Fulvio, Sommer Danika, Frangaj Brulinda, Tran Suzanne, Bielle Franck, Pollo Bianca, Paterra Rosina, Mokhtari Karima, Soni Rajesh Kumar, Peyre Matthieu, Eoli Marica, Papi Laura, Kalamarides Michel, Sanson Marc, Iavarone Antonio, Lasorella Anna

Abstract excerpt

LZTR1 is the substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in sporadic and syndromic cancer. We combined biochemical and genetic studies to identify LZTR1 substrates and interrogated their tumor-driving function in the context of LZTR1 loss-of-function mutations. Unbiased screens converged on EGFR and AXL receptor tyrosine kinases as LZTR1 interactors targeted for...

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Identifiers

PMID: 36445254
DOI: 10.1158/2159-8290.CD-22-0376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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