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Distinct D-box Motifs in SPD-2 Mediate APC/C <sup>FZR-1</sup> -Dependent Degradation and Centrosomal Localization in <i>Caenorhabditis elegans</i> Embryos

2025-10-15

Abstract excerpt

Centrosome duplication must be tightly regulated to maintain genomic stability. In Caenorhabditis elegans , the APC/C and co-activator FZR-1 function as negative regulators of centrosome duplication by targeting specific substrates for proteolytic degradation. While C. elegans SAS-5 and ZYG-1 have been identified as substrates of APC/C FZR-1 , the mechanism by which APC/C FZR-1 -dependent degradation influence...

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Literature Corpus work
522bfc79-446e-5d2c-a1bb-4c1b7b4291ef
DOI
10.1101/2025.10.14.682142
Open publication

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Distinct D-box Motifs in SPD-2 Mediate APC/C <sup>FZR-1</sup> -Dependent Degradation and Centrosomal Localization in <i>Caenorhabditis elegans</i> EmbryosDOI 10.1101/2025.10.14.682142
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