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Article

Functional and prognostic significance of the genomic amplification of frizzled 6 ( FZD6 ) in breast cancer

10 Nov 2016

Abstract excerpt

Frizzled receptors mediate Wnt ligand signalling, which is crucially involved in regulating tissue development and differentiation, and is often deregulated in cancer. In this study, we found that the gene encoding the Wnt receptor frizzled 6 (FZD6) is frequently amplified in breast cancer, with an increased incidence in the triple-negative breast cancer (TNBC) subtype. Ablation of FZD6 expression in mammary...

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PMID: 27859262
DOI: 10.1002/path.4841

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