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Article

Investigation of the 5q33.3 longevity locus and age-related phenotypes.

Aging - 13 Jan 2017

Nygaard Marianne, Thinggaard Mikael, Christensen Kaare, Christiansen Lene

Abstract excerpt

A large meta-analysis recently found the 5q33.3 locus to be associated with survival to ≥ 90 years and lower all-cause mortality, thus suggesting it as a third human longevity locus alongside APOE and FOXO3A. The 5q33.3 locus has previously been associated with blood pressure regulation and cardiovascular diseases in middle-aged individuals. However, part of the influence on mortality appears to be independent of...

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Identifiers

PMID: 28100865
DOI: 10.18632/aging.101156
PMCID: PMC5310666

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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