Article
FOXO3A genotype is strongly associated with human longevity.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008
Willcox Bradley J, Donlon Timothy A, He Qimei, Chen Randi, Grove John S, Yano Katsuhiko, Masaki Kamal H, Willcox D Craig, Rodriguez Beatriz, Curb J David
Abstract excerpt
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample...
Topics
- Aged
- Aged, 80 and over
- Case-Control Studies
- Forkhead Box Protein O3
- Forkhead Transcription Factors
- Genotype
- Health
- Humans
- Longevity
- Male
- Phenotype