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Article

FOXO3A genotype is strongly associated with human longevity.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008

Willcox Bradley J, Donlon Timothy A, He Qimei, Chen Randi, Grove John S, Yano Katsuhiko, Masaki Kamal H, Willcox D Craig, Rodriguez Beatriz, Curb J David

Abstract excerpt

Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample...

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PMID: 18765803
DOI: 10.1073/pnas.0801030105
PMCID: PMC2544566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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