Article
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Aging cell - 1 Aug 2011
Deelen Joris, Beekman Marian, Uh Hae-Won, Helmer Quinta, Kuningas Maris, Christiansen Lene, Kremer Dennis, van der Breggen Ruud, Suchiman H Eka D, Lakenberg Nico, van den Akker Erik B, Passtoors Willemijn M, Tiemeier Henning, van Heemst Diana, de Craen Anton J, Rivadeneira Fernando, de Geus Eco J, Perola Markus, van der Ouderaa Frans J, Gunn David A, Boomsma Dorret I, Uitterlinden André G, Christensen Kaare, van Duijn Cornelia M, Heijmans Bastiaan T, Houwing-Duistermaat Jeanine J, Westendorp Rudi G J, Slagboom P Eline
Abstract excerpt
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a...
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