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Article

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.

BMC medical genetics - 19 Sept 2007

Lunetta Kathryn L, D'Agostino Ralph B, Karasik David, Benjamin Emelia J, Guo Chao-Yu, Govindaraju Raju, Kiel Douglas P, Kelly-Hayes Margaret, Massaro Joseph M, Pencina Michael J, Seshadri Sudha, Murabito Joanne M

Abstract excerpt

BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a community-based sample. We report on 5 longevity and aging traits in up to 1345 Framingham Study participants from 330 families. Multivariable-adjusted residuals...

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Identifiers

PMID: 17903295
DOI: 10.1186/1471-2350-8-S1-S13
PMCID: PMC1995604

Genes

PON1
CYP19A1
GAPDH
KL
LEPR
PSEN1
SOD2
WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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