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Article

How Important Are Genes to Achieve Longevity?

International journal of molecular sciences - 18 May 2022

Caruso Calogero, Ligotti Mattia Emanuela, Accardi Giulia, Aiello Anna, Duro Giovanni, Galimberti Damiano, Candore Giuseppina

Abstract excerpt

Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with longevity in nearly all studies. This happens because the genetic determinants of longevity are dynamic and depend on the environmental history of a...

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Identifiers

PMID: 35628444
DOI: 10.3390/ijms23105635
PMCID: PMC9145989

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