Article
GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2015
Broer Linda, Buchman Aron S, Deelen Joris, Evans Daniel S, Faul Jessica D, Lunetta Kathryn L, Sebastiani Paola, Smith Jennifer A, Smith Albert V, Tanaka Toshiko, Yu Lei, Arnold Alice M, Aspelund Thor, Benjamin Emelia J, De Jager Philip L, Eirkisdottir Gudny, Evans Denis A, Garcia Melissa E, Hofman Albert, Kaplan Robert C, Kardia Sharon L R, Kiel Douglas P, Oostra Ben A, Orwoll Eric S, Parimi Neeta, Psaty Bruce M, Rivadeneira Fernando, Rotter Jerome I, Seshadri Sudha, Singleton Andrew, Tiemeier Henning, Uitterlinden André G, Zhao Wei, Bandinelli Stefania, Bennett David A, Ferrucci Luigi, Gudnason Vilmundur, Harris Tamara B, Karasik David, Launer Lenore J, Perls Thomas T, Slagboom P Eline, Tranah Gregory J, Weir David R, Newman Anne B, van Duijn Cornelia M, Murabito Joanne M
Abstract excerpt
BACKGROUND: The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. METHODS: We conducted a meta-analysis of genome-wide association studies including 6,036 longevity cases, age ≥90 years, and 3,757 controls that died between ages 55 and 80 years. We additionally attempted to...
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