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Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

23 Mar 2016

Abstract excerpt

Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have been identified. We undertook a Genome Wide Association Study (GWAS) using age at death of parents of middle-aged UK Biobank participants of European decent (n=75,244 with father's and/or mother's data, excluding early deaths). Genetic risk scores for 19 phenotypes (n=777 proven variants) were also tested. In GWAS, a...

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PMID: 27015805
DOI: 10.18632/aging.100930

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