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Article

FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease.

Aging - 1 Dec 2020

Chen Randi, Morris Brian J, Donlon Timothy A, Masaki Kamal H, Willcox D Craig, Davy Philip M C, Allsopp Richard C, Willcox Bradley J

Abstract excerpt

FOXO3 is a prominent longevity gene. To date, no-one has examined whether longevity-associated FOXO3 genetic variants protect against mortality in all individuals, or only in those with aging-related diseases. We therefore tested longevity-associated FOXO3 single nucleotide polymorphisms in a haplotype block for association with mortality in 3,584 elderly American men of Japanese ancestry, 2,512 with and 1,072...

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Source

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Identifiers

PMID: 33260156
DOI: 10.18632/aging.202175
PMCID: PMC7762472

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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