Article
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
Human molecular genetics - 15 Aug 2014
Deelen Joris, Beekman Marian, Uh Hae-Won, Broer Linda, Ayers Kristin L, Tan Qihua, Kamatani Yoichiro, Bennet Anna M, Tamm Riin, Trompet Stella, Guðbjartsson Daníel F, Flachsbart Friederike, Rose Giuseppina, Viktorin Alexander, Fischer Krista, Nygaard Marianne, Cordell Heather J, Crocco Paolina, van den Akker Erik B, Böhringer Stefan, Helmer Quinta, Nelson Christopher P, Saunders Gary I, Alver Maris, Andersen-Ranberg Karen, Breen Marie E, van der Breggen Ruud, Caliebe Amke, Capri Miriam, Cevenini Elisa, Collerton Joanna C, Dato Serena, Davies Karen, Ford Ian, Gampe Jutta, Garagnani Paolo, de Geus Eco J C, Harrow Jennifer, van Heemst Diana, Heijmans Bastiaan T, Heinsen Femke-Anouska, Hottenga Jouke-Jan, Hofman Albert, Jeune Bernard, Jonsson Palmi V, Lathrop Mark, Lechner Doris, Martin-Ruiz Carmen, Mcnerlan Susan E, Mihailov Evelin, Montesanto Alberto, Mooijaart Simon P, Murphy Anne, Nohr Ellen A, Paternoster Lavinia, Postmus Iris, Rivadeneira Fernando, Ross Owen A, Salvioli Stefano, Sattar Naveed, Schreiber Stefan, Stefánsson Hreinn, Stott David J, Tiemeier Henning, Uitterlinden André G, Westendorp Rudi G J, Willemsen Gonneke, Samani Nilesh J, Galan Pilar, Sørensen Thorkild I A, Boomsma Dorret I, Jukema J Wouter, Rea Irene Maeve, Passarino Giuseppe, de Craen Anton J M, Christensen Kaare, Nebel Almut, Stefánsson Kári, Metspalu Andres, Magnusson Patrik, Blanché Hélène, Christiansen Lene, Kirkwood Thomas B L, van Duijn Cornelia M, Franceschi Claudio, Houwing-Duistermaat Jeanine J, Slagboom P Eline
Abstract excerpt
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060...
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