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Article

Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2017

Zhang Zhenbo, Ciccia Francesco, Zeng Fanxing, Guggino Giuliana, Yee Kirby, Abdullah Hasan, Silverberg Mark S, Alessandro Riccardo, Triolo Giovanni, Haroon Nigil

Abstract excerpt

OBJECTIVE: The basic mechanisms underlying the pathogenesis of ankylosing spondylitis (AS) remain unresolved. We previously reported an association of the single-nucleotide polymorphism (SNP) rs2549782 in the endoplasmic reticulum aminopeptidase 2 gene (ERAP2) with AS. It is known that patients homozygous for the G allele (GG) of another ERAP2 SNP, rs2248374, lack expression of ERAP2 (ERAP2 null). The present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aminopeptidases
Share to CCAAT-Enhancer-Binding Proteins
Share to Endoplasmic Reticulum Chaperone BiP
Share to Heat-Shock Proteins
Share to HLA-B27 Antigen
Share to Spondylitis, Ankylosing
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Source

Identifiers

PMID: 28029742
DOI: 10.1002/art.40033

Genes

ERAP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.PMID 28029742Read ↗

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