ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers.

doi:10.1136/annrheumdis-2015-207467

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers.

Annals of the rheumatic diseases - 1 Nov 2015

Robinson Philip C, Lau Eugene, Keith Patricia, Lau Max C, Thomas Gethin P, Bradbury Linda A, Brown Matthew A, Kenna Tony J

Abstract excerpt

INTRODUCTION: Single nucleotide polymorphisms in ERAP2 are strongly associated with ankylosing spondylitis (AS). One AS-associated single nucleotide polymorphism, rs2248374, causes a truncated ERAP2 protein that is degraded by nonsense-mediated decay. Approximately 25% of the populations of European ancestry are therefore natural ERAP2 knockouts. We investigated the effect of this associated variant on HLA class...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Chaperone BiP

Share to Endoplasmic Reticulum Stress

Share to HLA-B27 Antigen

Share to Interleukin-22

Share to Receptors, Antigen, B-Cell

Share to Spondylitis, Ankylosing

Share to Transcription Factor CHOP

Source

Open in PubMed

Identifiers

PMID: 26088389
DOI: 10.1136/annrheumdis-2015-207467

Genes

ERAP2
ECD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers.PMID 26088389Read ↗

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.Semantic proximity Read ↗

Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.Semantic proximity Read ↗

Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility.Semantic proximity Read ↗

The influence of ERAP1 gene variants on clinical phenotype in ankylosing spondylitis.Semantic proximity Read ↗

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase 2 gene single nucleotide polymorphisms in association with susceptibility to ankylosing spondylitis in an Iranian population.Semantic proximity Read ↗

ERAP1 in the pathogenesis of ankylosing spondylitis.Semantic proximity Read ↗

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

Association of the genetic variants in the Endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibilitySemantic proximity Read ↗

ERAP2 protein allotypes show functional diversity in MHC-I antigen presentation in the human populationSemantic proximity Read ↗

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.