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Article

ERAP1 and ankylosing spondylitis.

Current opinion in immunology - 1 Feb 2013

Keidel Sarah, Chen Liye, Pointon Jennifer, Wordsworth Paul

Abstract excerpt

The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affecting the stability and processing of HLA-B27 but also influencing the peptide repertoire...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23452840
DOI: 10.1016/j.coi.2012.11.002

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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ERAP1 and ankylosing spondylitis.PMID 23452840Read ↗

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Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.Semantic proximity Read ↗

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Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Semantic proximity Read ↗

Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.Semantic proximity Read ↗

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibilitySemantic proximity Read ↗

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