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Article

Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.

Nature reviews. Rheumatology - 1 Aug 2010

Haroon Nigil, Inman Robert D

Abstract excerpt

Endoplasmic reticulum aminopeptidase 1 (ERAP1) and the closely related ERAP2 are involved in the final trimming of peptides within the endoplasmic reticulum for presentation by major histocompatibility complex (MHC) class I molecules. ERAP1 was found to be associated with ankylosing spondylitis (AS) in a genome-wide association study of nonsynonymous single nucleotide polymorphisms, and this association has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20531381
DOI: 10.1038/nrrheum.2010.85

Genes

ERAP1
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.PMID 20531381Read ↗

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