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Article

ERAP1 in the pathogenesis of ankylosing spondylitis.

Immunologic research - 1 Dec 2014

Reeves Emma, Elliott Tim, James Edward, Edwards Christopher J

Abstract excerpt

The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within ERAP1 as being associated with disease, in particular ankylosing spondylitis (AS). AS...

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Share to Aminopeptidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Histocompatibility Antigens Class I

Share to HLA-B27 Antigen

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Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 25434650
DOI: 10.1007/s12026-014-8576-2

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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