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Article

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.

Annals of the rheumatic diseases - 1 Apr 2012

Haroon Nigil, Tsui Florence W, Uchanska-Ziegler Barbara, Ziegler Andreas, Inman Robert D

Abstract excerpt

OBJECTIVES: The functional interaction of endoplasmic reticulum aminopeptidase 1 (ERAP1) with human leucocyte antigen (HLA)-B*27 could be important in the pathogenesis of ankylosing spondylitis (AS). AS is associated with B*27:04 and B*27:05, but not with B*27:06 and B*27:09. The authors studied the surface expression of peptide-HLA(pHLA)-B27 complexes and HLA class-I free heavy chains (FHCs) on peripheral blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22355039
DOI: 10.1136/annrheumdis-2011-200347

Genes

ERAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.PMID 22355039Read ↗

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.Semantic proximity Read ↗

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Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Semantic proximity Read ↗

ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface.Semantic proximity Read ↗

Inhibition of ERAP1 represses HLA-B27 free heavy chains expression on polarized macrophages and interrupts NK cells activation and function from ankylosing spondylitis.Semantic proximity Read ↗

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.Semantic proximity Read ↗

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibilitySemantic proximity Read ↗

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

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