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Article

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Annals of the rheumatic diseases - 1 May 2016

Chen Liye, Ridley Anna, Hammitzsch Ariane, Al-Mossawi Mohammad Hussein, Bunting Helen, Georgiadis Dimitris, Chan Antoni, Kollnberger Simon, Bowness Paul

Abstract excerpt

OBJECTIVE: Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key aminopeptidase in HLA class I presentation and can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We studied the effects of ERAP1 silencing/inhibition/variations on HLA-B27 FHC expression and Th17 responses in AS....

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Share to Aminopeptidases
Share to Antigen-Presenting Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B27 Antigen

Share to Immunoglobulin Heavy Chains

Share to Interleukin-2

Share to Minor Histocompatibility Antigens

Share to Spondylitis, Ankylosing

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Source

Open in PubMed Open full text

Identifiers

PMID: 26130142
DOI: 10.1136/annrheumdis-2014-206996
PMCID: PMC4853590

Genes

ERAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.PMID 26130142Read ↗

Inhibition of ERAP1 represses HLA-B27 free heavy chains expression on polarized macrophages and interrupts NK cells activation and function from ankylosing spondylitis.Semantic proximity Read ↗

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Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Semantic proximity Read ↗

Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.Semantic proximity Read ↗

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