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Article

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.

Genes and immunity - 1 Jan 2000

Kenna T J, Lau M C, Keith P, Ciccia F, Costello M-E, Bradbury L, Low P-L, Agrawal N, Triolo G, Alessandro R, Robinson P C, Thomas G P, Brown M A

Abstract excerpt

The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (AS) remains unclear. Genetic studies demonstrate that association with and interaction between polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA-B27 influence the risk of AS. It has been hypothesised that ERAP1-mediated HLA-B27 misfolding increases endoplasmic reticulum (ER) stress, driving an...

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Share to Aminopeptidases
Share to Endoplasmic Reticulum Chaperone BiP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to HLA-B27 Antigen

Share to Inflammation

Share to Minor Histocompatibility Antigens

Share to Spondylitis, Ankylosing

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Source

Identifiers

PMID: 25354578
DOI: 10.1038/gene.2014.62

Genes

ERAP1
EBP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.PMID 25354578Read ↗

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