Article
VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line.
Synapse (New York, N.Y.) - 1 Jun 2017
Bariselli Sebastiano, Bellone Camilla
Abstract excerpt
Several mutations within SHANK3 gene have been identified in Autism Spectrum Disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the disease. Here we show that, compared to a mouse model lacking SHANK3 proline-rich containing isoforms, in a mouse model lacking SHANK3 ANK(yrin)-domain containing isoforms, the...
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