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Article

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.

Autism research : official journal of the International Society for Autism Research - 1 Jan 2017

Jaramillo Thomas C, Speed Haley E, Xuan Zhong, Reimers Jeremy M, Escamilla Christine Ochoa, Weaver Travis P, Liu Shunan, Filonova Irina, Powell Craig M

Abstract excerpt

Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in Shank3 (Shank3E13 ). Insertion of a transcriptional stop cassette prior to exon 13 leads to loss of the...

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Identifiers

PMID: 27492494
DOI: 10.1002/aur.1664
PMCID: PMC5274551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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