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Article

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.

Translational psychiatry - 27 Apr 2018

Bey Alexandra L, Wang Xiaoming, Yan Haidun, Kim Namsoo, Passman Rebecca L, Yang Yilin, Cao Xinyu, Towers Aaron J, Hulbert Samuel W, Duffney Lara J, Gaidis Erin, Rodriguiz Ramona M, Wetsel William C, Yin Henry H, Jiang Yong-Hui

Abstract excerpt

We previously reported a new line of Shank3 mutant mice which led to a complete loss of Shank3 by deleting exons 4-22 (Δe4-22) globally. Δe4-22 mice display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior and excessive grooming, and a profound deficit in instrumental learning. However, the anatomical and neural circuitry underlying these...

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Identifiers

PMID: 29700290
DOI: 10.1038/s41398-018-0142-6
PMCID: PMC5919902

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Source receipt: pubmed, retrieved 7 Sept 2026.

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