Article

Behavioral regression in shank3Δex4-22 mice during early adulthood corresponds to cerebellar granule cell glutamatergic synaptic changes

2024-09-06

Abstract excerpt

<title>Abstract</title> Background: Shank3, a gene encoding a synaptic scaffolding protein, is implicated in autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS). Despite evidence of regression or worsening of ASD-like symptoms in individuals with PMS, the underlying mechanisms remain unclear. Although shank3 is highly expressed in the cerebellar cortical granule cells, its role in...

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Literature Corpus work: a765f5c2-60c8-5a3e-9047-7ceb62fc5610
DOI: 10.21203/rs.3.rs-4888950/v1

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