Article

Dysfunction of D2 dopamine receptor expressing neurons underlies manic-like behaviors in mice modeling SHANK3 duplication disorder

2021-07-12

Abstract excerpt

<title>Abstract</title> While the contributions of some genes to neuropsychiatric disorders are clear, the downstream neuronal effects are poorly understood. Over-expression of <italic>SHANK3</italic>, which encodes a key synaptic protein, causes neuropsychiatric phenotypes in humans and manic-like behavior in mice providing an opportunity to interrogate the role of SHANK3 in a subset of neurons that might und...

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Literature Corpus work: d7410403-0e6f-5e50-80b2-496d692ef513
DOI: 10.21203/rs.3.rs-646721/v1

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