Article

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

2020-11-03

Abstract excerpt

SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of excitatory synapses. Small microdeletions and point mutations in SHANK3 have been identified in a small subgroup of individuals with autism spectrum disorder (ASD) and intellectual disability. SHANK3 also plays a key role in the chromosome 22q13.3 microdeletion syndrome (Phelan–McDermid syndrome), which includes ASD and cognitiv...

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Literature Corpus work: 0b56b9d4-7078-51cc-8a2e-3cae3792ec33
DOI: 10.17615/ndgg-w424

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