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Article

Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Apr 2018

Kim Ryunhee, Kim Jihye, Chung Changuk, Ha Seungmin, Lee Seungjoon, Lee Eunee, Yoo Ye-Eun, Kim Woohyun, Shin Wangyong, Kim Eunjoon

Abstract excerpt

Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation and psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant (Shank2-/-) mice display several autistic-like behaviors, including social deficits, repetitive behaviors, hyperactivity, and anxiety-like behaviors. However, cell-type-specific contributions to these behaviors have remained largely...

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Identifiers

PMID: 29572432
DOI: 10.1523/JNEUROSCI.2684-17.2018
PMCID: PMC6596028

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Source receipt: pubmed, retrieved 7 Sept 2026.

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