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Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in <i>Shank3</i> -deficient rats

2023-12-05

Abstract excerpt

Social behaviors are crucial for human connection and belonging, often impacted in conditions like Autism Spectrum Disorder (ASD). The mesoaccumbens pathway (VTA and NAc) plays a pivotal role in social behavior and is implicated in ASD. However, the impact of ASD-related mutations on social reward processing remains insufficiently explored. This study focuses on the Shank3 mutation, associated with a rare genetic...

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Literature Corpus work
f975f05c-f8da-5a2a-8881-032563a5cf56
DOI
10.1101/2023.12.05.570134
Open publication

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Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in <i>Shank3</i> -deficient ratsDOI 10.1101/2023.12.05.570134
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