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Article

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2015

Speed Haley E, Kouser Mehreen, Xuan Zhong, Reimers Jeremy M, Ochoa Christine F, Gupta Natasha, Liu Shunan, Powell Craig M

Abstract excerpt

SHANK3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which mutations and deletions have been implicated in patients with idiopathic autism, Phelan-McDermid (aka 22q13 microdeletion) syndrome, and other neuropsychiatric disorders. In this study, we have created a novel mouse model of human autism caused by the insertion of a single guanine nucleotide into exon 21...

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Identifiers

PMID: 26134648
DOI: 10.1523/JNEUROSCI.3125-14.2015
PMCID: PMC4571502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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