Article
Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Nov 2013
Kouser Mehreen, Speed Haley E, Dewey Colleen M, Reimers Jeremy M, Widman Allie J, Gupta Natasha, Liu Shunan, Jaramillo Thomas C, Bangash Muhammad, Xiao Bo, Worley Paul F, Powell Craig M
Abstract excerpt
The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3 gene have not resulted in a complete loss of the predominant naturally occurring Shank3 isoforms. We have now characterized a homozygous Shank3 mutation in mice that deletes exon 21, including the Homer binding domain. In the homozygous state, deletion of...
Topics
- Adaptation, Physiological
- Animals
- Behavioral Symptoms
- Exploratory Behavior
- Hippocampus
- Locomotion
- Male
- Maze Learning
- Mice
- Mice, Inbred C57BL