Article
Shank3 deficits in the anteromedial bed nucleus of the stria terminalis trigger an anxiety phenotype in mice.
The European journal of neuroscience - 1 Jun 2023
Contestabile Alessandro, Casarotto Giulia, Musardo Stefano, Espinosa Pedro, Maltese Federica, Jiang Yong-Hui, Bellone Camilla, Glangetas Christelle
Abstract excerpt
Anxiety disorders are the most prevalent co-morbidity factor associated with the core domains of autism spectrum disorders (ASD). Investigations on potential common neuronal mechanisms that may explain the co-occurrence of ASD and anxiety disorders are still poorly explored. One of the key questions that remained unsolved is the role of Shank3 protein in anxiety behaviours. Firstly, we characterize the...
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