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Article

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.

The Journal of cell biology - 2 Jan 2017

Bruckner Joseph J, Zhan Hong, Gratz Scott J, Rao Monica, Ukken Fiona, Zilberg Gregory, O'Connor-Giles Kate M

Abstract excerpt

The strength of synaptic connections varies significantly and is a key determinant of communication within neural circuits. Mechanistic insight into presynaptic factors that establish and modulate neurotransmitter release properties is crucial to understanding synapse strength, circuit function, and neural plasticity. We previously identified Drosophila Piccolo-RIM-related Fife, which regulates neurotransmission...

Topics

Animals
Calcium Channels
Calcium Signaling
Cytoskeletal Proteins
Drosophila Proteins
Drosophila melanogaster
Electron Microscope Tomography
Genotype
Male
Microscopy, Confocal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron, Transmission

Mutation

Nerve Tissue Proteins

Neuronal Plasticity

Phenotype

Presynaptic Terminals

Protein Binding

Synaptic Potentials

Source

Open in PubMed Open full text

Identifiers

PMID: 27998991
DOI: 10.1083/jcb.201601098
PMCID: PMC5223599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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