The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.

doi:10.1523/JNEUROSCI.6164-10.2011

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Article

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Mar 2011

Stigloher Christian, Zhan Hong, Zhen Mei, Richmond Janet, Bessereau Jean-Louis

Abstract excerpt

The active zone (AZ) of chemical synapses is a specialized area of the presynaptic bouton in which vesicles fuse with the plasma membrane and release neurotransmitters. Efficient signaling requires synaptic vesicles (SVs) to be recruited, primed, and retained at the AZ, in close proximity to voltage-dependent calcium channels that are activated during presynaptic depolarization. The electron-dense specializations...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Calcium Signaling
Carrier Proteins
Electron Microscope Tomography
Electrophysiological Phenomena
Image Processing, Computer-Assisted
Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron, Transmission

Models, Molecular

Mutation

Neural Pathways

Parasympathetic Nervous System

Phosphoproteins

Presynaptic Terminals

Synaptic Vesicles

Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 21430140
DOI: 10.1523/JNEUROSCI.6164-10.2011
PMCID: PMC3077722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.PMID 21430140Read ↗

Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.Semantic proximity Read ↗

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.Semantic proximity Read ↗

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

Toolkits for detailed and high-throughput interrogation of synapses in <i>C. elegans</i>Semantic proximity Read ↗

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

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