Article
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.
Nature neuroscience - 1 Oct 2016
Böhme Mathias A, Beis Christina, Reddy-Alla Suneel, Reynolds Eric, Mampell Malou M, Grasskamp Andreas T, Lützkendorf Janine, Bergeron Dominique Dufour, Driller Jan H, Babikir Husam, Göttfert Fabian, Robinson Iain M, O'Kane Cahir J, Hell Stefan W, Wahl Markus C, Stelzl Ulrich, Loll Bernhard, Walter Alexander M, Sigrist Stephan J
Abstract excerpt
Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones (AZs). Efficacy of SV release depends on distance from SV to Ca(2+) channel, but molecular mechanisms controlling this are unknown. Here we found that distances can be defined by targeting two unc-13 (Unc13) isoforms to presynaptic AZ subdomains. Super-resolution and intravital imaging of developing Drosophila...
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