Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses.

eLife - 10 Jul 2018

Akbergenova Yulia, Cunningham Karen L, Zhang Yao V, Weiss Shirley, Littleton J Troy

Abstract excerpt

Neurons communicate through neurotransmitter release at specialized synaptic regions known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion events at Drosophila neuromuscular junctions, we analyzed the developmental and molecular determinants of release probability (Pr) for a defined connection with ~300 AZs. Pr was heterogeneous but represented a stable feature of each AZ. Pr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Exocytosis
Share to Neurotransmitter Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Presynaptic Terminals

Share to Synapses

Share to Synaptic Transmission

Share to Synaptic Vesicles

Share to Synaptotagmin I

Source

Open in PubMed Open full text

Identifiers

PMID: 29989549
DOI: 10.7554/eLife.38268
PMCID: PMC6075867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses.PMID 29989549Read ↗

Receptor clustering: nothing succeeds like success.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

Preferential localization of glutamate receptors opposite sites of high presynaptic release.Semantic proximity Read ↗

Activity-dependent site-specific changes of glutamate receptor composition in vivo.Semantic proximity Read ↗

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.Semantic proximity Read ↗

PP2A and GSK-3beta act antagonistically to regulate active zone development.Semantic proximity Read ↗

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

Unc-51 controls active zone density and protein composition by downregulating ERK signaling.Semantic proximity Read ↗

Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.Semantic proximity Read ↗

A screen for genes that regulate synaptic growth reveals mechanisms that stabilize synaptic strengthSemantic proximity Read ↗

Activity-independent prespecification of synaptic partners in the visual map of Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.