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Article

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.

The Journal of cell biology - 22 Feb 2010

Owald David, Fouquet Wernher, Schmidt Manuela, Wichmann Carolin, Mertel Sara, Depner Harald, Christiansen Frauke, Zube Christina, Quentin Christine, Körner Jorg, Urlaub Henning, Mechtler Karl, Sigrist Stephan J

Abstract excerpt

Active zones (AZs) are presynaptic membrane domains mediating synaptic vesicle fusion opposite postsynaptic densities (PSDs). At the Drosophila neuromuscular junction, the ELKS family member Bruchpilot (BRP) is essential for dense body formation and functional maturation of AZs. Using a proteomics approach, we identified Drosophila Syd-1 (DSyd-1) as a BRP binding partner. In vivo imaging shows that DSyd-1 arrives...

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Identifiers

PMID: 20176924
DOI: 10.1083/jcb.200908055
PMCID: PMC2828917

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.PMID 20176924Read ↗

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Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.Semantic proximity Read ↗

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Semantic proximity Read ↗

ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.Semantic proximity Read ↗

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.Semantic proximity Read ↗

PP2A and GSK-3beta act antagonistically to regulate active zone development.Semantic proximity Read ↗

Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

Assembly of synaptic active zones requires phase separation of scaffold molecules.Semantic proximity Read ↗

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.Semantic proximity Read ↗

Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release.Semantic proximity Read ↗

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