Article

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression

2021-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Synaptic proteins and synaptic transmission are under homeostatic control, but the relationship between these two processes remains enigmatic. Here, we systematically investigated the role of E3 ligases, key regulators of protein degradation-mediated proteostasis, in presynaptic homeostatic plasticity (PHP). An electrophysiology-based genetic screen of 157 E3 ligase-encoding genes at the Drosop...

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Literature Corpus work: 886fbd6e-f8dd-5d4b-ad7b-17b0b3210679
DOI: 10.1101/2021.06.16.448554

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