Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release.

Science (New York, N.Y.) - 19 May 2006

Kittel Robert J, Wichmann Carolin, Rasse Tobias M, Fouquet Wernher, Schmidt Manuela, Schmid Andreas, Wagh Dhananjay A, Pawlu Christian, Kellner Robert R, Willig Katrin I, Hell Stefan W, Buchner Erich, Heckmann Manfred, Sigrist Stephan J

Abstract excerpt

The molecular organization of presynaptic active zones during calcium influx-triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED (stimulated emission depletion) fluorescence microscopy. At brp mutant...

Topics

Action Potentials
Animals
Calcium Channels
Drosophila
Drosophila Proteins
Female
Larva
Male
Models, Neurological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Presynaptic Terminals

Synapses

Synaptic Vesicles

Source

Identifiers

PMID: 16614170
DOI: 10.1126/science.1126308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release.PMID 16614170Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.Semantic proximity Read ↗

Active zone compaction in presynaptic homeostatic potentiationSemantic proximity Read ↗

Blobby is a synaptic active zone assembly protein required for memory in Drosophila.Semantic proximity Read ↗

Naked dense bodies provoke depression.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

PP2A and GSK-3beta act antagonistically to regulate active zone development.Semantic proximity Read ↗

Rab3 dynamically controls protein composition at active zones.Semantic proximity Read ↗

Unc-51 controls active zone density and protein composition by downregulating ERK signaling.Semantic proximity Read ↗

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.